Kisspeptin is a crucial brain hormone that acts as the master switch for reproduction, stimulating the release of GnRH, which triggers puberty and maintains fertility by controlling sex hormones (like testosterone/estrogen) in men and women; it also influences mood, emotion, and behavior, and research shows potential as a treatment for low sex drive and infertility.

• Initiates Puberty & Reproduction:Kisspeptin activates Gonadotropin-Releasing Hormone (GnRH) neurons in the hypothalamus, starting the cascade that leads to sex hormone production.
• Regulates Sex Hormones:GnRH stimulates the pituitary gland to release LH and FSH, which then signal the testes and ovaries to produce testosterone and estrogen.
• Controls Hormonal Rhythms:It helps regulate the pulsatile release of hormones needed for normal reproductive cycles, working with other neuropeptides like nuerokinin B
• Influences Behavior & Mood:Beyond hormones, kisspeptin signals in brain areas related to emotions, affecting sexual desire, arousal, mood, and bonding behaviors.
• Integrates Signals:It acts as a central hub, responding to metabolic signals (like nutrition) and stress to adjust reproductive function.